Has improved treatment contributed to the declining rate of transition to psychosis in ultra-high-risk cohorts?

MJC Formica; LJ Phillips; JA Hartmann; AR Yung; SJ Wood; A Lin; GP Amminger; PD McGorry; B Nelson

Journal article

Has improved treatment contributed to the declining rate of transition to psychosis in ultra-high-risk cohorts?

MJC Formica, LJ Phillips, JA Hartmann, AR Yung, SJ Wood, A Lin, GP Amminger, PD McGorry, B Nelson

Schizophrenia Research | ELSEVIER | Published : 2022

DOI: 10.1016/j.schres.2020.04.028

Abstract

Background: The factors contributing to declining psychotic disorder transition rates in ultra-high-risk populations remain unclear. We examined the contribution of longitudinal changes in standard clinical treatment (‘treatment as usual’) to this decline. Method: An audit was conducted on 105 clinical files of patients who received standard care at a specialised ultra-high-risk service. The session notes of these files were quantified, allowing examination of treatment quantity, targets, psychotherapy, and medication. Differences in these aspects across patients' year of clinic entry were assessed. Variables with significant differences across years were examined using cox regression to ass..

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University of Melbourne Researchers

Lisa Phillips Author

Stephen Wood Author

Paul Amminger Author

Patrick McGorry Author

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Grants

Awarded by Colonial Foundation

Funding Acknowledgements

This work was supported by the National Health and Medical Research Council (NHMRC) Program grants 350241 and 566529 (ARY, PDM, SJW) and the Colonial Foundation. P.D.M. was supported by a Senior Principal Research Fellowship from the NHMRC (ID: 1060996) . G.P.A., A.R.Y., and B.N. were supported by NHMRC Senior Research Fellowships (IDs: 1080963, 566593, 1137687) . J.H. was supported by a McKenzie Fellowship, The University of Melbourne. S.J.W. was supported by an NHMRC Clinical Career Developmental Award (359223) . A.L. was supported by an NHMRC Career Development Fellowship (1148793) .